Damage to the endothelium contributes to the development of atherosclerosis, and hence to possible myocardial infarction and subsequent heart failu ⦠The heart wall is composed of connective tissue, endothelium, and cardiac muscle. Furthermore, this tissue has an embryonic mesodermal origin. The vascular endothelium is a monolayer of cells between the vessel lumen and the vascular smooth muscle cells. However, research over the last 25 years has shown that the endothelium is an active, multi-functional organ that plays a vital role in metabolic, immunologic, and cardiovascular health. Superiorly, is the second layer: a subendocardial connective tissue which is continuous with the connective tissue of the myocardium. Because it is adjacent to the bloodstream, the endothelium can signal a blood vesselâs muscle to respond to changes in pressure and inflammation. It is the cardiac muscle that enables the heart to contract and allows for the synchronization of the heartbeat. The tone of the endothelial layer also determines how much work is needed from the heart to pump blood through the body. Branches of the heartâs conduction system are immersed into the subendocardial layer. The endothelium is vital to the proper functioning in the heart, in particular due to its production of nitric oxide (NO) which regulates vascular tone. The inner layer lines the heart chambers and is made of endothelial cells. The endothelium is a layer of cells on the inside of blood vessels and the heart. The body tries to compensate for this by ordering the heart to pump harder to maintain normal flow by raising the blood pressure. Endothelia are considered the âbrainsâ of blood vessels. Damage to the cardiovascular endothelium not only develops with heart disease, but is one of the first steps on the path to heart disease, detectable even before structural changes to the vessel wall are apparent. Far from being inert, it is metabolically active and produces a variety of vasoactive mediators. The endothelial layer has a tone that contributes to the control of blood pressure. The endothelial cells ultimately determine the health of your blood vessels and play a ⦠Epicardium: the outer protective layer of the heart. Damaged endothelium therefore contributes to hypertension. The endothelium, which forms the inner cell lining of all blood vessels and lymphatics in the body, is a spatially distributed organ. Also, it lines the heart cavities. The endothelium weighs approximately 1 kg in the average patient and covers a total surface area of 4000 to 7000 square meters. Endothelium is a specialized type of epithelium found in the lining of blood and lymphatic vessels. The endothelium is ⦠The endothelium is a thin membrane that coats the inside of blood vessels and the heart. The heart wall is divided into three layers: epicardium, myocardium, and endocardium. 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